A lot depends on what you're trying to do.

I've run a 600 cfm smog Holley carb on my mildly built 462" Buick a few times and it ran ok.
Although, being jetted quite lean it didn't start pulling hard until it was on the verge of the secondaries popping open.

If you're just running around with the truck and the engine is close to stock, I'd just drive it and not worry about it.