I have spent a lifetime putting parts where they were never meant to be. So that is not an issue in general.

I an rebuilding my 63 F100, and needed to rebuild the floor to accommodate the E4OD. But, that is a big open floor. I also built a floor for the E4OD in my 55 Ford wagon. But that was a bare shell where I could easily do whatever was necessary

I am putting a 460/532 in my 73 Mach 1. That is a bolt-in, I have done it a couple times before, but only with a C6. And this is a running car. Anybody know what I will encounter when I try to put an E4OD in it?