OK-to get away from basic differances-

You have stated that you are a carb lovin man and also that you have a Holley -

Leave the static compression RATIO where its at because with the higher alt you won't have too much actual in the cylinder pressure. Get some Holley jets down to around the upper 50s or lower 60s up to mid 70s and a gathering of power valves from 3.5 to 8.5. Does your carb have a seconary metering block or is it one of those thin cheapie plates? If its a plate purchase a seconary metering block kit(will include longer bolts) and also make sure your fuel line set up will work with the longer spacing.
For a starting point Jet the carb down about 4 jet sizes (assuming you are savvy enough(in that thin air breathing those over rich exhaust fumes) to use a consistant brand/source of gas) When you get it running with a decent drivability on the primaries( up until seconary opening point) you can then start on the power stuff with different springs in the vacume opening diaphram and the seconary jets

Then when you do go on a trip where you come down to farm level fiels, you can easily change back to jets that are 2 sizes smaller than whats in the carb as shipped (I like #70 for the 3310 carbs pri)

At least with the Holley you don't have to take off the carb and on a chev the distri isn't in the way of the primary bowl bolts.

Since the air is thin up there, use a pretty open aircleaner to let in as much as you can, choose a cam that gives the atmospere time to push in (remember the engine doesn't suck, the atmosphere equalizes the pressure ) and have as free flowing exhaust as you can stand in the car-might need to try 2 or 3 different type mufflers to get rid of drone sound effects.

And since you are at higher alt you can probably run a couple more degrees of timing if you have good fuel as your absolute cylinder pressure will be lower than when you come down out of the hills for a road trip.

And there are now some systems that you can program ignition timing for carbed engines that work real nice and you can mount them remotely( where you can reach them) in the drivr area