Don,
I do most of my painting with DuPont Chromabase and Five Star X-treme clear (all acrylic urethanes) and I haven't had any adhesion problems. If you are using lacquer primer, you just have to let it get completely dry before applying the urethane topcoat so that you don't trap any of the lacquer solvents under the paint. That's why I said it has to dry 24-48 hours before topcoating. If you trap solvent under the paint, it will cause blistering and / or peeling.


Another annoying problem I have had is with body filler causing urethane paints to discolor. This doesn't show up right away, but comes on gradually over a few months after applying the paint. It is worst on light colors (white, yellow, light blue) and any colors containing red pigment. I have tried different fillers, from cheap stuff to premium, and still had the problem. I almost religiously use some kind of sealer before painting to combat this problem.