A couple of things come to mind. First, interference at the steering box if you plan to retain the stock front suspension/steering. Most of the time, this can be overcome by moving the motor/trans toward the passenger side of the car. As long as you keep the crankshaft centerline perpendicular to the rear axle centerline, you won't have any u-joint problems. Chrysler moved the big V8's as much as 3 inches from body centerline on OEM cars back in the day. The other thing is headers and you're on your own there. Maybe block huggers from a company like Sanderson would work or you may have to build your own or use manifolds, I don't know. It may be worth some time spent to search these header manufacturer websites or even call a few of them. You never know, they may have a set on the shelf made for your application.
http://www.roadsters.com/engines/#Headers