Assuming you are talking about welding splatter burning the floor coating...

All depends on the coating. Some can take it and a lot of them can't. The best thing to do is tell the salesperson at the paint store what is going to be done in the garage. The various paint manufacturers make epoxy floor coatings that will :

resist burning
resist various chemicals
resist bacteria buildup
remain a non-skid surface even when wet


Just tell the salesperson what you need and they should steer you in the right direction. Also, (no disrespect intended) I'd avoid going to one of the building supply superstores like Home Depot. Your best bet is a dealer that handles industrial grade coatings.