Yea, an old, old thread back from the crypt... I will throw some info in here though because it will get hits now and it may help someone else who could be wondering about this...
Let me expand on what johnegoins touched on...
An S10 is a "front steer" suspension. The steering box is in front of the suspension. What this means is, once you get the frame installed and want to mount the front fenders and grille, you will find the steering box is sitting right where the front of the left front fender wants to be. The box will actually have to "poke" out the front of the car... Not good for aesthetics in my book. The S10 frame is not a good swap candidate for the earlier full fendered cars.
The MII suspension is a perfect fit though as Dave said and would be a much easier addition to any of these style cars or trucks.
Mark